Claudin 2 (CLDN2) (NM_020384) Human Recombinant Protein

• Background:

  This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]

• Synonyms:

  SP82

• Gene ID:

  9075

• UniProt:

  P57739

• Accession Number mRNA:

  NM_020384

• Chromosomal Location:

  Xq22.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

• Field of Research:

  Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  24.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CLDN2

• Species:

  Human

• Protein ID:

  NP_065117

• Overview:

  Recombinant protein of human claudin 2 (CLDN2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9075

• Uniprot URL:

  https://www.uniprot.org/uniprot/P57739

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_020384

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_065117