Cbl c (CBLC) (NM_012116) Human Recombinant Protein

• Background:

  This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

• Synonyms:

  CBL-3; CBL-SL; RNF57

• Gene ID:

  23624

• UniProt:

  Q9ULV8

• Accession Number mRNA:

  NM_012116

• Chromosomal Location:

  19q13.32

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis

• Field of Research:

  Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  52.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CBLC

• Species:

  Human

• Protein ID:

  NP_036248

• Overview:

  Recombinant protein of human Cas-Br-M (murine) ecotropic retroviral transforming sequence c (CBLC), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23624

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9ULV8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012116

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036248