KDEL Receptor (KDELR1) (NM_006801) Human Recombinant Protein

• Background:

  Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

• Synonyms:

  ERD2; ERD2.1; HDEL; PM23

• Gene ID:

  10945

• UniProt:

  P24390

• Accession Number mRNA:

  NM_006801

• Chromosomal Location:

  19q13.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Vibrio cholerae infection

• Field of Research:

  Vibrio cholerae infection

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  24.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  KDELR1

• Species:

  Human

• Protein ID:

  NP_006792

• Overview:

  Recombinant protein of human KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (KDELR1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10945

• Uniprot URL:

  https://www.uniprot.org/uniprot/P24390

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006801

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006792