Cadherin 16 (CDH16) (NM_004062) Human Recombinant Protein

• Background:

  This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

• Synonyms:

  Cadherin 16; cadherin 16, KSP-cadherin; kidney-specific cadherin; KSP-cadherin

• Gene ID:

  1014

• UniProt:

  O75309

• Accession Number mRNA:

  NM_004062

• Chromosomal Location:

  16q22.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  87.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CDH16

• Species:

  Human

• Protein ID:

  NP_004053

• Overview:

  Recombinant protein of human cadherin 16, KSP-cadherin (CDH16)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1014

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75309

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004062

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004053