Cyclin A1 (CCNA1) (NM_003914) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  CT146

• Gene ID:

  8900

• UniProt:

  P78396

• Accession Number mRNA:

  NM_003914

• Chromosomal Location:

  13q13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Acute myeloid leukemia, Cell cycle, Pathways in cancer, Progesterone-mediated oocyte maturation

• Field of Research:

  Acute myeloid leukemia, Cell cycle, Pathways in cancer, Progesterone-mediated oocyte maturation

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  52.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CCNA1

• Species:

  Human

• Protein ID:

  NP_003905

• Overview:

  Recombinant protein of human cyclin A1 (CCNA1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8900

• Uniprot URL:

  https://www.uniprot.org/uniprot/P78396

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003914

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003905