APJ Receptor (APLNR) (NM_005161) Human Recombinant Protein

• Background:

  This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]

• Synonyms:

  AGTRL1; APJ; APJR; HG11

• Gene ID:

  187

• UniProt:

  P35414, B3KQN4, B2RDH3

• Accession Number mRNA:

  NM_005161

• Chromosomal Location:

  11q12.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Neuroactive ligand-receptor interaction

• Field of Research:

  Neuroactive ligand-receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, GPCR, Transmembrane

• Molecular Weight:

  42.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  APLNR

• Species:

  Human

• Protein ID:

  NP_005152

• Overview:

  Recombinant protein of human apelin receptor (APLNR)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/187

• Uniprot URL:

  https://www.uniprot.org/uniprot/P35414

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005161

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005152