TIE1 (NM_005424) Human Recombinant Protein

• Background:

  This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

• Synonyms:

  JTK14; LMPHM11; TIE

• Gene ID:

  7075

• UniProt:

  P35590

• Accession Number mRNA:

  NM_005424

• Chromosomal Location:

  1p34.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  124.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TIE1

• Species:

  Human

• Protein ID:

  NP_005415

• Overview:

  Recombinant protein of human tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7075

• Uniprot URL:

  https://www.uniprot.org/uniprot/P35590

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005424

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005415