BMPR2 (NM_001204) Human Recombinant Protein

• Background:

  This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020]

• Synonyms:

  BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK

• Gene ID:

  659

• UniProt:

  Q13873

• Accession Number mRNA:

  NM_001204

• Chromosomal Location:

  2q33.1-q33.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  112.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BMPR2

• Species:

  Human

• Protein ID:

  NP_001195

• Overview:

  Recombinant protein of human bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/659

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13873

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001204

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001195