Carboxypeptidase H (CPE) (NM_001873) Human Recombinant Protein

• Background:

  This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]

• Synonyms:

  CPH; IDDHH

• Gene ID:

  1363

• UniProt:

  P16870, A0A384N679

• Accession Number mRNA:

  NM_001873

• Chromosomal Location:

  4q32.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Type I diabetes mellitus

• Field of Research:

  Type I diabetes mellitus

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protease, Secreted Protein

• Molecular Weight:

  50.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CPE

• Species:

  Human

• Protein ID:

  NP_001864

• Overview:

  Recombinant protein of human carboxypeptidase E (CPE)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1363

• Uniprot URL:

  https://www.uniprot.org/uniprot/P16870

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001873

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001864