Munc 13 4 (UNC13D) (NM_199242) Human Recombinant Protein

• Background:

  This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]

• Synonyms:

  FHL3; HLH3; HPLH3; Munc13-4

• Gene ID:

  201294

• UniProt:

  Q70J99

• Accession Number mRNA:

  NM_199242

• Chromosomal Location:

  17q25.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  123.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  UNC13D

• Species:

  Human

• Protein ID:

  NP_954712

• Overview:

  Recombinant protein of human unc-13 homolog D (C. elegans) (UNC13D)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/201294

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q70J99

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_199242

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_954712