Cytokeratin 8 (KRT8) (NM_002273) Human Recombinant Protein

• Background:

  This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

• Synonyms:

  CARD2; CK-8; CK8; CYK8; K2C8; K8; KO

• Gene ID:

  3856

• UniProt:

  P05787

• Accession Number mRNA:

  NM_002273

• Chromosomal Location:

  12q13.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  53.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  KRT8

• Species:

  Human

• Protein ID:

  NP_002264

• Overview:

  Recombinant protein of human keratin 8 (KRT8)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3856

• Uniprot URL:

  https://www.uniprot.org/uniprot/P05787

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002273

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002264