FKBP51 (FKBP5) (NM_004117) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

• Synonyms:

  AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10

• Gene ID:

  2289

• UniProt:

  Q13451, Q2TA84

• Accession Number mRNA:

  NM_004117

• Chromosomal Location:

  6p21.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  51 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  FKBP5

• Species:

  Human

• Protein ID:

  NP_004108

• Overview:

  Recombinant protein of human FK506 binding protein 5 (FKBP5), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2289

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13451

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004117

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004108