SPANXA1 (NM_013453) Human Recombinant Protein

• Background:

  Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]

• Synonyms:

  CT11.1; CT11.3; NAP-X; SPAN-X; SPAN-Xa; SPAN-Xb; SPANX; SPANX-A

• Gene ID:

  30014

• UniProt:

  Q9NS26

• Accession Number mRNA:

  NM_013453

• Chromosomal Location:

  Xq27.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  10.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SPANXA1

• Species:

  Human

• Protein ID:

  NP_038481

• Overview:

  Recombinant protein of human sperm protein associated with the nucleus, X-linked, family member A1 (SPANXA1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/30014

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NS26

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_013453

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_038481