PLA2G10 (NM_003561) Human Recombinant Protein

• Background:

  This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

• Synonyms:

  GXPLA2; GXSPLA2; SPLA2; sPLA2-X

• Gene ID:

  8399

• UniProt:

  O15496

• Accession Number mRNA:

  NM_003561

• Chromosomal Location:

  16p13.12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway

• Field of Research:

  Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein, Transmembrane

• Molecular Weight:

  18 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PLA2G10

• Species:

  Human

• Protein ID:

  NP_003552

• Overview:

  Recombinant protein of human phospholipase A2, group X (PLA2G10)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8399

• Uniprot URL:

  https://www.uniprot.org/uniprot/O15496

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003561

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003552