Nectin 2 (NECTIN2) (NM_001042724) Human Recombinant Protein

• Background:

  This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Synonyms:

  CD112; HVEB; PRR2; PVRL2; PVRR2

• Gene ID:

  5819

• UniProt:

  Q92692

• Accession Number mRNA:

  NM_001042724

• Chromosomal Location:

  19q13.32

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Adherens junction, Cell adhesion molecules (CAMs)

• Field of Research:

  Adherens junction, Cell adhesion molecules (CAMs)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  54.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NECTIN2

• Species:

  Human

• Protein ID:

  NP_001036189

• Overview:

  Recombinant protein of human poliovirus receptor-related 2 (herpesvirus entry mediator B) (PVRL2), transcript variant delta

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5819

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q92692

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001042724

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001036189