SARM (SARM1) (NM_015077) Human Recombinant Protein

• Background:

  Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  HSARM1; HsTIR; MyD88-5; SAMD2; SARM

• Gene ID:

  23098

• UniProt:

  Q6SZW1, Q0D2N8, Q05B42

• Accession Number mRNA:

  NM_015077

• Chromosomal Location:

  17q11.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  79.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SARM1

• Species:

  Human

• Protein ID:

  NP_055892

• Overview:

  Recombinant protein of human sterile alpha and TIR motif containing 1 (SARM1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23098

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6SZW1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015077

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055892