PDE6 gamma (PDE6G) (NM_002602) Human Recombinant Protein

• Background:

  This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

• Synonyms:

  PDEG; RP57

• Gene ID:

  5148

• UniProt:

  P18545

• Accession Number mRNA:

  NM_002602

• Chromosomal Location:

  17q25.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Field of Research:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  9.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDE6G

• Species:

  Human

• Protein ID:

  NP_002593

• Overview:

  Recombinant protein of human phosphodiesterase 6G, cGMP-specific, rod, gamma (PDE6G), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5148

• Uniprot URL:

  https://www.uniprot.org/uniprot/P18545

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002602

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002593