LRRFIP1 (NM_004735) Human Recombinant Protein

• Background:

  Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; TRIP

• Gene ID:

  9208

• UniProt:

  Q32MZ4, E9PGZ2

• Accession Number mRNA:

  NM_004735

• Chromosomal Location:

  2q37.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  86.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LRRFIP1

• Species:

  Human

• Protein ID:

  NP_004726

• Overview:

  Recombinant protein of human leucine rich repeat (in FLII) interacting protein 1 (LRRFIP1), transcript variant 4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9208

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q32MZ4

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004735

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004726