AMPK alpha 1 (PRKAA1) (NM_006251) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) . AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

• Synonyms:

  AMPK; AMPKa1; AMPK alpha 1

• Gene ID:

  5562

• UniProt:

  Q13131

• Accession Number mRNA:

  NM_006251

• Chromosomal Location:

  5p13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway, mTOR signaling pathway, Regulation of autophagy

• Field of Research:

  Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway, mTOR signaling pathway, Regulation of autophagy

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  63.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PRKAA1

• Species:

  Human

• Protein ID:

  NP_006242

• Overview:

  Recombinant protein of human protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5562

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13131

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006251

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006242