EDARADD (NM_080738) Human Recombinant Protein

• Background:

  This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Synonyms:

  ECTD11A; ECTD11B; ED3; EDA3

• Gene ID:

  128178

• UniProt:

  Q8WWZ3

• Accession Number mRNA:

  NM_080738

• Chromosomal Location:

  1q42.3-q43

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  23.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  EDARADD

• Species:

  Human

• Protein ID:

  NP_542776

• Overview:

  Recombinant protein of human EDAR-associated death domain (EDARADD), transcript variant B

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/128178

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8WWZ3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_080738

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_542776