MAPKAP Kinase 2 (MAPKAPK2) (NM_004759) Human Recombinant Protein

• Background:

  This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  MAPKAP-K2; MK-2; MK2

• Gene ID:

  9261

• UniProt:

  P49137

• Accession Number mRNA:

  NM_004759

• Chromosomal Location:

  1q32.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  MAPK signaling pathway, Neurotrophin signaling pathway, VEGF signaling pathway

• Field of Research:

  MAPK signaling pathway, Neurotrophin signaling pathway, VEGF signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  42 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MAPKAPK2

• Species:

  Human

• Protein ID:

  NP_004750

• Overview:

  Recombinant protein of human mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9261

• Uniprot URL:

  https://www.uniprot.org/uniprot/P49137

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004759

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004750