ZAK (MAP3K20) (NM_016653) Human Recombinant Protein

• Background:

  This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM) . This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Synonyms:

  AZK; CNM6; MLK7; mlklak; MLT; MLTK; MLTKalpha; MLTKbeta; MRK; pk; SFMMP; ZAK

• Gene ID:

  51776

• UniProt:

  Q9NYL2

• Accession Number mRNA:

  NM_016653

• Chromosomal Location:

  2q31.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  MAPK signaling pathway, Tight junction

• Field of Research:

  MAPK signaling pathway, Tight junction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  91 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MAP3K20

• Species:

  Human

• Protein ID:

  NP_057737

• Overview:

  Recombinant protein of human sterile alpha motif and leucine zipper containing kinase AZK (ZAK), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51776

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NYL2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016653

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057737