ATP7B (NM_000053) Human Recombinant Protein

• Background:

  This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019]

• Synonyms:

  PWD; WC1; WD; WND

• Gene ID:

  540

• UniProt:

  P35670, A0A024RDX3, B7ZLR4

• Accession Number mRNA:

  NM_000053

• Chromosomal Location:

  13q14.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  157.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ATP7B

• Species:

  Human

• Protein ID:

  NP_000044

• Overview:

  Recombinant protein of human ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/540

• Uniprot URL:

  https://www.uniprot.org/uniprot/P35670

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000053

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000044