Oxytocin neurophysin 1 (OXT) (NM_000915) Human Recombinant Protein

• Background:

  This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

• Synonyms:

  OT; OT-NPI; OXT-NPI

• Gene ID:

  5020

• UniProt:

  P01178, X5D7M6

• Accession Number mRNA:

  NM_000915

• Chromosomal Location:

  20p13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Secreted Protein

• Molecular Weight:

  10.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  OXT

• Species:

  Human

• Protein ID:

  NP_000906

• Overview:

  Recombinant protein of human oxytocin, prepropeptide (OXT)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5020

• Uniprot URL:

  https://www.uniprot.org/uniprot/P01178

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000915

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000906