ErbB 3 (ERBB3) (NM_001005915) Human Recombinant Protein

• Background:

  This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

• Synonyms:

  C-erbB-3; c-erbB3; ErbB-3; erbB3-S; FERLK; HER3; LCCS2; MDA-BF-1; p45-sErbB3; p85-sErbB3; p180-ErbB3

• Gene ID:

  2065

• UniProt:

  P21860

• Accession Number mRNA:

  NM_001005915

• Chromosomal Location:

  12q13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Calcium signaling pathway, Endocytosis, ErbB signaling pathway

• Field of Research:

  Calcium signaling pathway, Endocytosis, ErbB signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Adult stem cells, Druggable Genome, Protein Kinase, Secreted Protein, Stem cell - Pluripotency, Transmembrane

• Molecular Weight:

  18.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ERBB3

• Species:

  Human

• Protein ID:

  NP_001005915

• Overview:

  Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant s

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2065

• Uniprot URL:

  https://www.uniprot.org/uniprot/P21860

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001005915

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001005915