CENPA (NM_001809) Human Recombinant Protein

• Background:

  Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

• Synonyms:

  CenH3; CENP-A

• Gene ID:

  1058

• UniProt:

  P49450

• Accession Number mRNA:

  NM_001809

• Chromosomal Location:

  2p23.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  15.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CENPA

• Species:

  Human

• Protein ID:

  NP_001800

• Overview:

  Recombinant protein of human centromere protein A (CENPA), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1058

• Uniprot URL:

  https://www.uniprot.org/uniprot/P49450

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001809

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001800