DAXX (NM_001141970) Human Recombinant Protein

• Background:

  This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

• Synonyms:

  BING2; DAP6; EAP1; SMIM40

• Gene ID:

  1616

• UniProt:

  B4E1C1

• Accession Number mRNA:

  NM_001141970

• Chromosomal Location:

  6p21.32

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway

• Field of Research:

  Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency, Transcription Factors

• Molecular Weight:

  82.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DAXX

• Species:

  Human

• Protein ID:

  NP_001135442

• Overview:

  Recombinant protein of human death-domain associated protein (DAXX), transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1616

• Uniprot URL:

  https://www.uniprot.org/uniprot/B4E1C1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001141970

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001135442