CACNA2D2 (NM_001174051) Human Recombinant Protein

• Background:

  Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

• Synonyms:

  CACNA2D; CASVDD

• Gene ID:

  9254

• UniProt:

  Q9NY47

• Accession Number mRNA:

  NM_001174051

• Chromosomal Location:

  3p21.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway

• Field of Research:

  Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Ion Channels: Other

• Molecular Weight:

  130.3

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CACNA2D2

• Species:

  Human

• Protein ID:

  NP_001167522

• Overview:

  Recombinant protein of human calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant 3.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9254

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NY47

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001174051

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001167522