TRPC6 (NM_004621) Human Recombinant Protein

• Background:

  The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) . [provided by RefSeq, Mar 2009]

• Synonyms:

  FSGS2; TRP6

• Gene ID:

  7225

• UniProt:

  Q9Y210

• Accession Number mRNA:

  NM_004621

• Chromosomal Location:

  11q22.1

• Expression System:

  E. coli

• Tag:

  N-His ABP

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

• Molecular Weight:

  26.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TRPC6

• Species:

  Human

• Protein ID:

  NP_004612

• Overview:

  Purified recombinant protein of Human transient receptor potential cation channel, subfamily C, member 6 (TRPC6), Met1-Phe102, with N-terminal His-ABP tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7225

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y210

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004621

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004612