CLACP (COL25A1) (NM_198721) Human Recombinant Protein

• Background:

  This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410) . A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

• Synonyms:

  AMY; CFEOM5; CLAC; CLAC-P; CLACP

• Gene ID:

  84570

• UniProt:

  Q9BXS0

• Accession Number mRNA:

  NM_198721

• Chromosomal Location:

  4q25

• Expression System:

  E. coli

• Tag:

  N-His ABP

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea

• Function:

  Transmembrane

• Molecular Weight:

  23.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  COL25A1

• Species:

  Human

• Protein ID:

  NP_942014

• Overview:

  Purified recombinant protein of Human collagen, type XXV, alpha 1 (COL25A1), transcript variant 1, Lys573-Gln653, with N-terminal His-ABP tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/84570

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BXS0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_198721

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_942014