Arpc5 (NM_026369) Mouse Recombinant Protein

• Background:

  Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  5830443F10Rik; p16-Arc

• Gene ID:

  67771

• UniProt:

  Q9CPW4

• Accession Number mRNA:

  NM_026369

• Chromosomal Location:

  1 G3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  16.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Arpc5

• Species:

  Mouse

• Protein ID:

  NP_080645

• Overview:

  Purified recombinant protein of Mouse actin related protein 2/3 complex, subunit 5 (Arpc5), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/67771

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9CPW4

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_026369

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_080645