Litaf (NM_019980) Mouse Recombinant Protein

• Background:

  Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352) . Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4 (By similarity) . May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005, PubMed:21980379) . May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:12355436, PubMed:15025820, PubMed:16954198, PubMed:21980379, PubMed:22160695) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  3222402J11Rik; C85531; N4WBP3; TBX1

• Gene ID:

  56722

• UniProt:

  Q9JLJ0

• Accession Number mRNA:

  NM_019980

• Chromosomal Location:

  16 A1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  16.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Litaf

• Species:

  Mouse

• Protein ID:

  NP_064364

• Overview:

  Purified recombinant protein of Mouse LPS-induced TN factor (Litaf), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/56722

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9JLJ0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_019980

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_064364