Bpifa1 (NM_011126) Mouse Recombinant Protein

• Background:

  Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (By similarity) . Plays a role in the innate immune responses of the upper airways (PubMed:23499554) . Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554) . Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity) . Plays a role in the airway inflammatory response after exposure to irritants (By similarity) . May attract macrophages and neutrophils (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  LUNX; NASG; Plunc; SPLUNC1; SPURT

• Gene ID:

  18843

• UniProt:

  P97361

• Accession Number mRNA:

  NM_011126

• Chromosomal Location:

  2 H1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  28.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Bpifa1

• Species:

  Mouse

• Protein ID:

  NP_035256

• Overview:

  Purified recombinant protein of Mouse BPI fold containing family A, member 1 (Bpifa1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/18843

• Uniprot URL:

  https://www.uniprot.org/uniprot/P97361

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_011126

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_035256