Lrrc8c (NM_133897) Mouse Recombinant Protein

• Background:

  Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723) . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E) ; channel characteristics depend on the precise subunit composition (By similarity) . May play a role in adipogenesis (PubMed:15564382, PubMed:15184384, PubMed:21804215) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AD158; AI326115; E430036I04Rik; fad158

• Gene ID:

  100604

• UniProt:

  Q8R502

• Accession Number mRNA:

  NM_133897

• Chromosomal Location:

  5 E5

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  92.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Lrrc8c

• Species:

  Mouse

• Protein ID:

  NP_598658

• Overview:

  Purified recombinant protein of Mouse leucine rich repeat containing 8 family, member C (Lrrc8c), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/100604

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8R502

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_133897

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_598658