TFE3 (NM_006521) Human Recombinant Protein

• Background:

  This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Synonyms:

  BHLHe33; RCCP2; RCCX1; TFEA

• Gene ID:

  7030

• UniProt:

  P19532, A0A024QZ23

• Accession Number mRNA:

  NM_006521

• Chromosomal Location:

  Xp11.23

• Expression System:

  Sf9

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  62 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TFE3

• Species:

  Human

• Protein ID:

  NP_006512

• Overview:

  Recombinant protein of human transcription factor binding to IGHM enhancer 3 (TFE3), with N-terminal polyhistidine tag, expressed in sf9 cells.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7030

• Uniprot URL:

  https://www.uniprot.org/uniprot/P19532

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006521

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006512