Kallikrein 8 (KLK8) (NM_007196) Human Recombinant Protein

• Background:

  Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

• Synonyms:

  HNP; NP; NRPN; PRSS19; TADG14

• Gene ID:

  11202

• UniProt:

  O60259

• Accession Number mRNA:

  NM_007196

• Chromosomal Location:

  19q13.41

• Expression System:

  Sf9

• Tag:

  C-DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol

• Function:

  Druggable Genome, Secreted Protein, Transmembrane

• Molecular Weight:

  25 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  KLK8

• Species:

  Human

• Protein ID:

  NP_007187

• Overview:

  Recombinant protein of human kallikrein-related peptidase 8 (KLK8), transcript variant 1, residues 33-260aa, with C-terminal DDK tag, expressed in sf9 cells.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/11202

• Uniprot URL:

  https://www.uniprot.org/uniprot/O60259

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007196

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_007187