SNX6 (NM_021249) Human Recombinant Protein

• Background:

  This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

• Synonyms:

  MSTP010; TFAF2

• Gene ID:

  58533

• UniProt:

  Q9UNH7

• Accession Number mRNA:

  NM_021249

• Chromosomal Location:

  14q13.1

• Expression System:

  E. coli

• Tag:

  N-GST and C-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.

• Function:

  Druggable Genome, ES Cell Differentiation/IPS

• Molecular Weight:

  61.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SNX6

• Species:

  Human

• Protein ID:

  NP_067072

• Overview:

  Purified recombinant protein of Human sorting nexin 6 (SNX6), transcript variant 1, full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/58533

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UNH7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021249

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_067072