IL12RB1 Mouse Monoclonal Antibody [Clone ID: LBI1A6]

• Background:

  The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

• Synonyms:

  CD212; IL-12R-BETA1; IL12RB; IMD30

• Gene Name:

  Interleukin 12 receptor subunit beta 1

• Gene ID:

  3594

• UniProt:

  P42701

• Conjugation:

  Unconjugated

• Related Pathways:

  Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Field of Research:

  Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, Transmembrane

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  IL12RB1

• Overview:

  IL12RB1 mouse monoclonal antibody, clone LBI1A6

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3594

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42701