IL23A Antibody (Center) [APR33523G]

• Background:

  Tissue Location: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level) .

• Synonyms:

  Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, IL23A, SGRF

• Gene Name:

  IL23A

• Gene ID:

  51561

• UniProt:

  Q9NPF7

• Chromosomal Location:

  Secreted. Note=Secreted upon association with IL12B

• Applications:

  WB, FC

• Dilution:

  FC--1:25 WB--1:2000

• Function:

  Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

• Molecular Weight:

  20730

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IL23A Antibody (Center) [APR33523G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=51561

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NPF7