IL11RA Antibody (C-Term) [ApR04902G]

• Background:

  Tissue Location: Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2 (PubMed:7670098) . Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.

• Synonyms:

  Interleukin-11 receptor subunit alpha, IL-11 receptor subunit alpha, IL-11R subunit alpha, IL-11R-alpha, IL-11RA, IL11RA

• Gene Name:

  HGNC:5967

• Gene ID:

  3590

• UniProt:

  Q14626

• Chromosomal Location:

  [Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein [Isoform HCR2]: Secreted

• Applications:

  WB

• Dilution:

  WB--1:2000

• Function:

  Receptor for interleukin-11 (IL11) . The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable) . Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

• Molecular Weight:

  45222

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IL11RA Antibody (C-Term) [ApR04902G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3590

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q14626