TLR2 Antibody - N-terminal region: Biotin (ARP59037_P050-Biotin)

• Gene Name:

  Toll-like receptor 2

• Gene Aliases:

  TIL4, CD282

• Gene ID:

  7097

• Swiss Prot:

  O60603

• Accession Number:

  NP_003255

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Dog

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human TLR2

• Target:

  TLR2 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

• Partner Proteins:

  ATG16L1; IRF3; CREBBP; CLEC7A; CLEC4M; TIRAP; MAPK8IP3; TICAM1; TOLLIP; TLR10; TLR6; LY96; RIPK2; TRIP6; MYD88; RAC1; TLR1; IRAK1; HSP90B1; HRAS; SFTPA1; PIK3R1; HMGB1; CD14; TLR2

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Dog: 86%; Human: 100%; Rat: 79%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  90kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  784

• NCBI Gene Symbol:

  TLR2

• Protein Name:

  Toll-like receptor 2

• Nucleotide Accession Number:

  NM_003264