TBC1D10C Antibody - N-terminal region: FITC (ARP55894_P050-FITC)

• Gene Name:

  TBC1 domain family, member 10C

• Gene Aliases:

  EPI64C, CARABIN

• Gene ID:

  374403

• Swiss Prot:

  Q8IV04

• Accession Number:

  NP_940919

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human TBC1D10C

• Target:

  TBC1D10C inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. TBC1D10C acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]) .[supplied by OMIM].

• Partner Proteins:

  NOTCH2NL; KRTAP13-1; KLHL12; KRTAP5-9; HOXA1; APP; PPP3R2

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rat: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  50kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  446

• NCBI Gene Symbol:

  TBC1D10C

• Protein Name:

  Carabin

• Nucleotide Accession Number:

  NM_198517