ULK1 Antibody - N-terminal region: FITC (ARP54261_P050-FITC)

• Gene Name:

  Unc-51-like kinase 1 (C. elegans)

• Gene Aliases:

  ATG1, ATG1A, UNC51, hATG1, Unc51.1

• Gene ID:

  8408

• Swiss Prot:

  O75385

• Accession Number:

  NP_003556

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N-terminal region of Human ULK1

• Target:

  ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.

• Partner Proteins:

  SESN2; SQSTM1; ATG16L1; EXOC8; EXOC2; BECN1; RALB; AMBRA1; ULK1; UBC; TRAF6; MBP; ATG13; MAP1LC3C; MAP1LC3A; MAP1LC3B; GABARAPL1; GABARAPL2; GABARAP; MLST8; RPTOR; MTOR; PPP1CA; ATG4B; CDC37; G3BP1; RB1CC1; USP10; PRKAG1; PRKAB2; PRKAA2; PRKAA1; SYNGAP1

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  112kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  1050

• NCBI Gene Symbol:

  ULK1

• Protein Name:

  Serine/threonine-protein kinase ULK1

• Nucleotide Accession Number:

  NM_003565