Anti-PAX5 PE

• Description:

  PAX5 is a transcription factor expressed in hematopoietic cells of B cell line, and partially also in the nervous system. It is important for B cell development and differentiation, but its expression must finally be be suppressed to enable plasma cell maturation. PAX5 thus affects the balance between B cell proliferation and antibody production. Its overexpression is associated with many lymphomas.

• Certification:

  RUO

• Immunogen:

  GST-tagged recombinant mouse PAX5

• Target Antigen:

  PAX5

• Clone:

  1H9

• Applications:

  FC-IC (QC tested)

• Concentration:

  0.1 mg/mL

• Format:

  PE

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *Liu GJ, Cimmino L, Jude JG, Hu Y, Witkowski MT, McKenzie MD, Kartal-Kaess M, Best SA, Tuohey L, Liao Y, Shi W, Mullighan CG, Farrar MA, Nutt SL, Smyth GK, Zuber J, Dickins RA: Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia. Genes Dev. 2014 Jun 15;28 (12) :1337-50. , URL: https://pubmed.ncbi.nlm.nih.gov/24939936/, *Villanueva-Hernández S, Razavi MA, van Dongen KA, Stadler M, de Luca K, Beyersdorf N, Saalmüller A, Gerner W, Mair KH: Co-expression of the B-cell key transcription factors Blimp-1 and IRF4 identifies plasma cells in the pig. Front Immunol. 2022 Apr 8:13:854257. , URL: https://pubmed.ncbi.nlm.nih.gov/35464468/

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The rat monoclonal antibody 1H9 recognizes transcription factor PAX5 (intracellular antigen) .

• Applications Notes:

  6

• Species:

  Mouse, Human

• Isotype:

  Rat IgG2a kappa