ADP-Ribosylation Cycle Inhibitor Mix

• Description:

  The ADP-Ribosylation Cycle Inhibitor Mix is a 500x cocktail of two inhibitors (AZD2281 and PDD00017273) . AZD2281 (Olaparib) is a PARP inhibitor with broad pan-PARP activity, which blocks a large proportion of the ADP-ribosylation of proteins. PDD00017273 is a potent, selective poly (ADP-ribose) glycohydrolase (PARG) inhibitor that blocks PARG-mediated de-ribosylation of proteins. Used together, these two inhibitors “freeze” the state of cellular ribosylation at the time the mix is applied to the cells. This product is designed to supplement a cell lysis buffer of choice to prevent post-lysis changes in the ADP-ribosylation status of extracted proteins.

• Molecular Formula:

  Olaparib: C24H23FN4O3; PDD00017273: C23H26N6O4S

• Shipping Conditions:

  -80°C

• Storage Conditions:

  Upon receipt store at -80°C. Stable for 6 months from date of receipt, when stored as directed.

• Calculated Molecular Weight:

  Olaparib: 434.46; PDD00017273: 514.62

• Formulation:

  5 mM AZD2281 (Olaparib) (BPS Bioscience #27003) and 5 mM PDD00017273 in 100% DMSO (Dimethyl sulfoxide) .

• CAS Number:

  Olaparib: 763113-22-0; PDD00017273: C23H26N6O4S