(αR)-Cyclopropaneacetamide-Exatecan

• UNSPSC Description:

  (αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent. (αR)-Cyclopropaneacetamide-Exatecan inhibits U87MG and SK-BR-3 cells proliferation, with IC50s of 8.11 and 2.31 μM[1].

• Target Antigen:

  ADC Cytotoxin; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/αr-cyclopropaneacetamide-exatecan.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@H](C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O

• Molecular Weight:

  533.55

• References & Citations:

  [1]Haiqing H, et, al. Antibody-drug conjugate and medical use thereof. WO2021190564A1.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2414254-37-6