Anti-Integrin beta-7 [FIB27]

• Gene Name:

  [ITGB7]

• NCBI Gene ID:

  3695

• Reactivity:

  Human, Mouse

• Storage Conditions:

  Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.

• Specificity:

  FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.

• Other Gene Names:

  [ITGB7; ITGB7]

• Short Name:

  [Integrin beta-7]

• Other Product Names:

  [integrin beta-7; Integrin beta-7; integrin beta-7; integrin subunit beta 7; Gut homing receptor beta subunit]

• NCBI GI Number:

  4504777

• NCBI Accession Number:

  NP_000880.1

• NCBI GB Accession Number:

  NP_000880.1

• Uniprot Accession Number:

  P26010

• CAS Number:

  9007-83-4