Aβ1–42 aggregation inhibitor 1

• UNSPSC Description:

  Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with the IC50 value of 2.64 μM and 1.29 μM, respectively. Aβ1-42 aggregation inhibitor 1 inhibits self-mediated Aβ1-42 aggregation by 51.29% at a concentration of 25 μM. Aβ1-42 aggregation inhibitor 1 has the potential for the research of anti-Alzheimer's disease[1].

• Target Antigen:

  Amyloid-β; Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aβ1-42-aggregation-inhibitor-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCN1C2=CC=C(/C=C/C3=CC=C(C=C3)NC(NCCN4CCCC4)=S)C=C2C5=CC=CC=C51

• Molecular Weight:

  468.66

• References & Citations:

  [1]Dushyant V Patel, et al. Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents. Bioorg Chem. 2020 Aug;101:103977.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2439107-75-0