Proguanylin Human Recombinant Protein

• Description:

  Proguanylin Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain (a.a 22-115) containing 104 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 11.5kDa (calculated) .

• Synonyms:

  Guanylin Precursor; Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Gap-IGUCA2; STARA; GUANYLIN

• Gene Name:

  GUCA2A

• UniProt:

  Q02747

• Reactivity:

  Human

• Tissue Specificity:

  Highly expressed in ileum and colon. Found in plasma.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 90.0% as determined by SDS-PAGE.

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  Prepare about 0.5mg/ml working stock solution with deionized water and let the lyophilized pellet dissolve completely. Proguanylin is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

• Function:

  Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.

• Other Gene Names:

  Guanylin

• Subcellular Location:

  Secreted.