Anti-FCGRT Antibody Picoband® (iFluor647 Conjugate)

• Background:

  IgG receptor FcRn large subunit p51?is a?protein?that in humans is encoded by the?FCGRT?gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation.?In addition, it is postulated that long-range cis inactivation of the?FCGRT?gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The?FCGRT?gene is closely situated to the DMPK gene, which is mutant in DM.?

• Description:

  Boster Bio Anti-FCGRT Antibody Picoband® catalog # PB9867. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  IgG receptor FcRn large subunit p51;FcRn;IgG Fc fragment receptor transporter alpha chain;Neonatal Fc receptor;Fcgrt;Fcrn;

• Gene Name:

  IgG receptor FcRn large subunit p51

• UniProt:

  Q61559

• Host:

  Rabbit

• Reactivity:

  Mouse

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E. coli-derived mouse FCGRT recombinant protein (Position: Q54-D291). Mouse FCGRT shares 70.2% and 92.4% amino acid (aa) sequence identity with human and rat FCGRT, respectively.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.

• Applications:

  ELISA,IHC,WB

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.

• Storage Conditions:

  Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Mouse, By Heat
  ELISA, 0.1-0.5μg/ml, -
  Western blot, 0.1-0.5μg/ml, Mouse
  

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein.

• Protein Name:

  IgG receptor FcRn large subunit p51